I came across this error today, when using the HTML5 client and VMware Update Manager (VUM);
Response with status: 401 OK for URL: https://<FQDN of VUM server>ui/vum-ui/rest/vcobjects/urn:vmomi:HostSystem:host-10:478c8cfc-c88e-4fdb-9e1a-93d899697bf7/isUpdateSupported
Turns out this is something that only affects Firefox since 6.7 U1 and VMware have a KB article on it here; https://kb.vmware.com/s/article/59696
UPDATE – VMware have now fixed this in 6.7 U2 of vCenter which is available from Vmware Downloads